Monday, July 18, 2016

Keto 7: I don’t believe you.

i8i            You’ll be surprised at how often you hear something like this, though you usually don’t hear it directly. People will say things like, “That doesn’t sound right” or “Eating too much fat is dangerous” or “Epidemiological studies show that [insert ominous thing here]” or “Look at what happened to Atkins on a low-carb diet.” Sometimes, they’re right. The Standard American Diet [SAD] is definitely too high in fat, especially saturated and trans. It is not especially salubrious, and the extra fat (surprise) is usually stored. When your brain runs on ketones rather than glucose, though, the fat isn’t stored. It’s used to feed your brain and muscles. The key here is that you have to stay in ketosis. You cannot use both glucose and ketones. Your body will opt for the glucose. Unless you are basically using the glucose as soon as it goes in, your liver is going to start storing the glucose and using it instead of the fat. You’re going to have problems if you eat high fat and high carb.
            So, they ask, what stupid magazine or blog did you read all this crap on? I’m glad you asked. While I did initially read about it on more general sites, I wound up doing some of my own research as well. (Thanks, Google Scholar!) Most of the existing studies deal with mice, but there was one of particular interest. This was an observational study rather than an RCT, so it is not perfect; however, the results are enlightening.
            Essentially, the trial followed a group of people who were using ketogenic diets to treat their epilepsy. (Ketogenic diets have long been used to significantly decrease the number of seizures that patients have when drug treatments are not effective.) The study spanned 5 years and studied markers like body composition, body fat percentage, bone minerals, [and so on]. The conclusions were that the ketogenic diet did not have an appreciable negative effect on any of the markers. It just cut the number of seizures in half. Unless you believe that epilepsy somehow has a protective effect against fat accumulation in a high-fat, low-carbohydrate diet, then this study indicates that a ketogenic diet in and of itself is not inherently harmful.
            Another group that indicates this is the Inuit. They eat a ton of fat, mostly in the form of blubber, and a very, very low-carbohydrate diet. Still, they tend to be reasonably healthy.
            Now, any idiot can find a study, particularly an observational study, showing that diets higher in fat tend to be associated with poorer health. The problem they have is the same problem that most observational studies have: it’s next to impossible to isolate single characteristics. The observational studies don’t have much of anything to say about carbohydrate intake, or whether or not the people tend to listen to their doctors when making choices about what to do. It’s like many of the other observational studies that have returned results that did not hold up in random-controlled trials: something else caused the results. In at least some cases, researchers speculate that a.) people who adopt one habit said to be healthy (such as eating less fat or eating breakfast) are more likely to adopt other habits said to be healthy (such as eating whole foods, not smoking, limiting alcohol, and getting regular exercise), and b.) one of the latter habits is more likely to be responsible for the health improvements than is one of the former.

            Additionally, recent studies, including random-controlled trials and meta-studies have failed to replicate many of the supposed problems associated with higher fat consumption, particularly when that is coupled with other healthy habits. In fact, some studies have shown the opposite effect.

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